WHAT IS AUTOLOGOUS DENDRITIC CELLS TREATMENT?
Dendritic cells (DCs) are a type of immune cell that play a crucial role in initiating and regulating immune responses. While dendritic cell therapy is an area of ongoing research for various autoimmune diseases, including lupus, its specific benefits and applications in lupus treatment are still being explored. However, here are some potential benefits of dendritic cells for lupus:
- Immune modulation: Dendritic cells can regulate immune responses by presenting antigens to other immune cells, such as T cells and B cells. By controlling the presentation of self-antigens, dendritic cells can potentially help restore immune tolerance and prevent the immune system from attacking healthy tissues in lupus.
- Tolerance induction: Dendritic cells can be modified or manipulated ex vivo to promote immune tolerance. These modified dendritic cells can be loaded with lupus-specific antigens and reintroduced into the body, promoting the development of regulatory T cells that suppress harmful immune responses and reduce disease activity in lupus.
- Suppression of autoreactive B cells: In lupus, autoreactive B cells produce autoantibodies that contribute to tissue damage. Dendritic cells can interact with B cells and regulate their activation and differentiation. Through the induction of regulatory B cells or suppression of autoreactive B cells, dendritic cells may help reduce the production of autoantibodies in lupus.
- Cytokine modulation: Dendritic cells produce various cytokines that can influence the immune response. By manipulating dendritic cells, it may be possible to modulate the production and release of specific cytokines to achieve a more balanced immune response in lupus.
- Induction of immune tolerance to specific autoantigens: Dendritic cell therapy can be customized to induce immune tolerance to specific autoantigens involved in lupus. By targeting these autoantigens, dendritic cells can potentially reduce autoimmune activity, decrease inflammation, and mitigate tissue damage.
A NEW APPROACH BASED ON SOLID SCIENCE
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